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Gemeprost is expected to pass into breast milk but there are no data to confirm this. The elimination half-life of gemeprost is 24 hours after intravenous administration, and, therefore, interruption of breastfeeding for 24 hours after a vaginal dose would seem appropriate. Where a surgical method of termination is used, the effects of local or general anaesthetics must be considered when advising on the safety of breastfeeding. The above recommendations are based on limited clinical evidence supported by pharmacokinetic observations.

Test your knowledge about taking acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs). Abdominal cramps, pain or discomfort diarrhea dizziness drowsiness gastrointestinal bleeding headache heartburn high blood pressure nausea or vomiting peptic ulcer swelling of feet rash ringing in the ears. Misoprostol can cause miscarriage and birth defects. Do not take if you are pregnant. Liver enzymes should be checked within 4 to 8 weeks of starting any type of diclofenac. Compared to other NSAIDs, this drug has a lower risk of gastric ulcers but an increased risk of abdominal pain and diarrhea.Before taking any type of NSAID, tell your doctor if you drink alcohol or take blood thinners (including warfarin), ACE inhibitors, lithium or furosemide. Also report any sensitivity or allergy to aspirin or similar drugs. All non-aspirin NSAIDs may cause an increased risk of serious blood clots, heart attack and stroke, which can be fatal. Treatment with NSAIDs following a first heart attack increases the risk of death in the first year after the heart attack (compared to not using NSAIDs after a first heart attack).